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KCE reports vol. 6A Prenatale zorg 229
Study Ref Population Intervention Outcomes Results Comments Study
Type
steps (DETS) couple
screening
£ 21,000
Preconceptional SETS
Corresponding values in
screening
terms of the number of
Preconceptional DETS
avoided births:
screening
For 1: £ 177,000
School screening
For 2: £ 213,000
Neonatal screening
For 3: £ 223,000
For 4: £ 258,000
For 5: £ 367,000
For 6: £ 178,000
Verhe
y et
al.,
1998
105 Costs of screening were
based on a theoretical
population of 100,000
couples a year, who were
eligible for screening
Costs of medical care
were based on the
records of 81 CF patients
(the Netherlands)
Assumptions about
effectiveness were based
on expert opinion,
Evaluation of the effects,
costs and savings for a
preconceptional couple
screening programme for CF
carriers using either SETS
(start by testing one partner)
or DETS (test both partners
immediately)
Comparator = no screening
Effects
Costs
Savings
SETS and DETS prenatal
screening strategies and
preconceptional SETS
screening have a
favourable cost-saving
balance in the Netherlands
(under a wide range of
assumptions)
The costs of screening
would equal the savings if
approximately 8,000
couples (10%) were
screened yearly in the
Netherlands
Sensitivity analysis showed
that the savings were no
longer greater than costs
if, at participation of 50%,
the percentage of carrier
couples who used prenatal
diagnostics dropped to
Limited generalisability
of the cost results
Average lifetime medical
costs for a CF patient
were estimated at
Dfl541,894
EE
EL