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KCE reports vol. 6A Prenatale zorg 227
Study Ref Population Intervention Outcomes Results Comments Stud
y
Miedzbrodzka
et al., 1995
103 Setting: hospital antenatal
clinic serving a regional
population
en (couples) attending for
booking antenatal visit at
less than 17 weeks
gestation with no family
history of CF
Offering counselling and
carrier testing for CF
(stepwise or no couple
screening)
Uptake rates
Anxiety
Knowledge of CF and
carrier status (both
partners)
change when screening
moved from a research to
a routine service
Of 22 high-risk couples
identified entirely through
screening, 20 (91%) opted
for prenatal diagnosis
4 of 22 high-risk couples
returned for second and 2
for third monitored
pregnancies. In all 8 cases
where affected fetuses
were identified, pregnancy
was terminated
The same uptake rates for
both approaches: 90%
With stepwise screening
women identified as
carriers had high levels of
anxiety when results were
received. This dissipated
with a reassuring partners
result to levels similar to
those receiving negative
results.
Of those receiving
negative results, women
who had stepwise
screening were
significantly less anxious
type
Prag
matic
RT
EL
2a