Download het volledig rapport (302 p.) - KCE

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<strong>KCE</strong> reports vol. 6A Prenatale zorg 226 Study Ref Population Intervention Outcomes Results Comments Stud y Cunningham and Marshall, 1998 101 Infants diagnosed as having CF (by sweat test or genotyping, or both) in the seven years before antenatal testing (1984-90) and the first years of antenatal testing (1991-95) Brock, 1996 102 25,000 couples screened in Edinburgh, from 1992 till 1996 first on research basis and then routinely To compare the incidence of CF in the period before antenatal screening with the incidence in the period after antenatal screening Results were more pronounced when partners had similar perceptions Main reason given for not participating in screening was lack of time to attend the educational session. Couples, who lacked the time to attend, perceived more benefits from screening than couples reporting other reasons for non-participation. Incidence of CF Average incidence in 1984- 1990: 4.6 Average incidence in 1991- 1995: 1.6 Reduction in the incidence of 65% (greater than that accounted for by prenatal diagnosis and termination = 36%) Screening for CF Take-up rates Take-up rates for the twostep and couple models of delivery are very similar at about 70% Take-up rates did not The numbers are small type CO M EL 3 LS 3
<strong>KCE</strong> reports vol. 6A Prenatale zorg 227 Study Ref Population Intervention Outcomes Results Comments Stud y Miedzbrodzka et al., 1995 103 Setting: hospital antenatal clinic serving a regional population en (couples) attending for booking antenatal visit at less than 17 weeks gestation with no family history of CF Offering counselling and carrier testing for CF (stepwise or no couple screening) Uptake rates Anxiety Knowledge of CF and carrier status (both partners) change when screening moved from a research to a routine service Of 22 high-risk couples identified entirely through screening, 20 (91%) opted for prenatal diagnosis 4 of 22 high-risk couples returned for second and 2 for third monitored pregnancies. In all 8 cases where affected fetuses were identified, pregnancy was terminated The same uptake rates for both approaches: 90% With stepwise screening women identified as carriers had high levels of anxiety when results were received. This dissipated with a reassuring partners result to levels similar to those receiving negative results. Of those receiving negative results, women who had stepwise screening were significantly less anxious type Prag matic RT EL 2a
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