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KCE reports vol. 6A Prenatale zorg 219
Study Ref Population Intervention Outcomes Results
identifiable mutation, the partner ´ s sample
is tested. The couple ´s test result is
considered positive only when both carry
identifiable mutations. These couples are
offered counselling and diagnostic testing.
Information about carrier status is not
provided routinely, only on request.
Occasional modifications: simultaneous
analysis of samples from two partners,
report of carrier status of both partners
Comment
s
Study type EL
What is the knowledge about CF and what is the attitude towards carrier screening?
Study Ref Population Intervention Outcomes Results Comments Study
Henneman et
al., 2002
93 17 identified carriers
15 partners of carriers
with negative test results
794 other participants
Assessment 6
months after testing
by questionnaire
Impact,
understanding of
test results,
satisfaction in
terms of:
Reproductive
intentions of the
participants
Level of concern
Perception of
health
Level of
knowledge of CF
Recall
Understanding of
the test results
Attitude toward
carrier screening
None of the carriers changed
reproductive intentions
8 participants were worried about
their results, including 4 carriers
Participants who attended a GP for
pre-test education were less worried
than those who attend an educational
group session
7 carriers felt less healthy
Positive test results, high level of
knowledge of CF, high level of
education, attending an educational
session, and previously heard of CF
were predictors of a correct
EL
type
EV 3