Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 213
Study Ref Population Intervention Outcomes Results
Pregnancy loss (3 RCTs, n =
9067): Peto OR 1.33, 95% CI
1.17 to 1.52
Comments Study
type
EL
Alfirevic, 4 [324] 3 RCTs, 1832 Amniocentesis vs. Sampling failure
Failure (3 RCTs, n = 1832):
SR 1a
2000
women
transabdominal CVS at 9
0.4% vs. 2%, RR 0.23, 95% CI
to 14 weeks gestation Total pregnancy loss 0.08 to 0.65
RCOG
Guideline
No. 8,
2000
4 [307] N/A Amniocentesis vs. no
amniocentesis at 16 to 18
weeks (n = 4606 women)
Early amniocentesis
(before 14 weeks, n =
2183) vs. amniocentesis at
15 weeks or later (n =
2185)
Excess loss rate for
amniocentesis vs. no
amniocentesis
For early amniocentesis vs.
late amniocentesis:
Rates of fetal loss
and fetal talipes
following
amniocentesis
Procedure analysis
Pregnancy loss (3 RCTs, n =
1832): 6.2% vs. 5%, RR 1.24,
95% CI 0.85 to 1.81
Excess miscarriage rate in
amniocentesis group: 1%
Early vs. late amniocentesis:
Total fetal loss, 7.6%
vs. 5.9%, p = 0.012
Fetal talipes, 1.3% vs.
0.1%, p = 0.0001
Procedure reported
difficult, 10.1% vs.
4.0%, p < 0.0001
Amniotic fluid
leakage at < 22
weeks, 3.5% vs.
1.7%, p = 0.0007
Multiple needle
insertion, 5.4% vs.
2.1%, p < 0.0001
First attempt
success, 96.9% vs.
99.6%, p < 0.0001
SR 1b