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KCE reports vol. 6A Prenatale zorg 210
Study Ref Population Intervention Outcomes Results
100%), false positive rate 21%
(range 20% to 21%)
Comments Study
type
Bindra et
al., 2002
4 [609] 15,030 pregnant
women in London
from 1999 to 2001
Screening for DownÊs
syndrome by nuchal
translucency, free betahCG
and PAPP-A and
maternal age at 11 to 14
weeks
Detection rates at cutoff
rate of 1/300
False positive rate for 75%
and 85% detection rate
Detection rate with false
positive rate fixed at 5%
Uptake of prenatal
diagnosis
Sensitivities for maternal age
< 35 years:
For cutoff rates 1/250 to
1/295, 57% (range 53% to
58%), false positive rate 4%
(range 3% to 6%)
82 cases of DownÊs
syndrome identified
False positive rate at 75%
detection rate:
Maternal age alone, 27.7%
Maternal age, free beta-hCG,
and PAPP-A, 10.1%
Maternal age and NT, 2.6%
Maternal age, NT, free betahCG
and PAPP-A, 0.9%
False positive rate at 85%
detection rate:
Maternal age alone, 46.4%
Maternal age, free beta-hCG,
and PAPP-A, 15.2%
Maternal age and NT, 9.1%
Maternal age, NT, free betahCG
and PAPP-A, 3.0%
Detection rate for fixed false
positive rate of 5%:
By maternal age alone, 30.5%
Maternal age, free beta-hCG
EL
CH 2b