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KCE reports vol. 6A Prenatale zorg 209
Study Ref Population Intervention Outcomes Results
Specificity 0.96 (0.94 to
0.97)
Fetal loss 2.0
Comments Study
type
Dick, 1994 4 [608] 4 cohort studies Comparison of
proportion of DownÊs
syndrome pregnancies
identified through triple
testing with the total
number of DownÊs
syndrome pregnancies
Conde-
Agudelo
and
Kafury-
Geota,
1998
4 [320] 20 cohort studies,
194,326 pregnant
women
Meta-analysis of
effectiveness of triple
marker screening for
DownÊs syndrome
Renal pyelectasis (95% CI):
Sensitivity 0.02 (0.01 to
0.06)
Specificity 0.99 (0.98,
1.0)
Fetal loss 2.6
Detection rates Range 48% to 91% with false
positive rate
of 3.2 to 6%, respectively
(cutoff rates
from 1/190 to 1/274 used)
Sensitivities and false
positive rates
When varying cutoff rates
were accounted for, triple
marker screening in the 2nd
trimester with AFP, hCG,
and uE3 combined with
maternal age offered 50%
detection rate in women <
35 years with 5% false
positive rate
Sensitivities for maternal age
º 35 years:
For cutoff rates 1/190 to
1/200, 89% (range 78% to
100%), false positive rate 25%
(range 20% to 29%)
For cutoff rates 1/250 to
1/295, 80% (range 75% to
SR of
CH
SR of
CH
EL
2b
2b