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<strong>KCE</strong> reports vol. 6A Prenatale zorg 202 Study Ref Population Intervention Outcomes Results Comment s 1. f. Umbilical and uterine artery Doppler ultrasound At 28 weeks, compared with women with cervical lengths above the 75th percentile: women at or below 75% (CL40 mm) had RR 2.8, 95% CI 1.41 to 5.56 women at or below 5o% (CL 35 mm) had RR 3.52, 95% CI 1.79 to 6.92 women at or below 25% (CL30 mm) had RR 5.39, 95% CI 2.82 to 10.28 women at or below 10% (CL26 mm) had RR 9.57, 95% CI 5.24 to 17.48 women at or below 5% (CL22 mm) had RR 13.88, 95% CI 7.68 to 25.10 women at or below 1% (CL13 mm) had RR 24.94, 95% CI 13.81 to 45.04 Sensitivity for at 24 and 28 weeks for less than or equal to 30 mm CL: 54% and 70% Specificity for at 24 and 28 weeks for less than or equal to 30 mm CL: 76% and 69% What is the effect of Doppler ultrasound on perinatal outcomes? Study Ref Population Intervention Outcomes Results Comment Bricker and Neilson, 2001 4 [575] 5 RCTs, 14,388 pregnant women Routine Doppler ultrasound vs. no/concealed/selective Doppler ultrasound Antenatal admission Further Doppler ultrasound Birth weight Antenatal admission: (3 RCTs, n = 9359) Peto OR 1.05, 95% CI 0.95 to 1.15 Further Doppler ultrasound: (1 RCT, n = 3898) Peto OR 1.57 95% CI 1.30 to 1.90 Birth weight: (mean, SD) (1 RCT, n = 2016) s Study type EL Study type EL SR 1a
<strong>KCE</strong> reports vol. 6A Prenatale zorg 203 Study Ref Population Intervention Outcomes Apgar score Results WMD 27.000 95% CI 74.235 to 20.235 Apgar score < 7 at 5 minutes: (4 RCTs, n = 11375) Peto OR 0.88 95% CI 0.56 to 1.40 Comment s Serial ultrasound and Doppler ultrasound vs. selective ultrasound Admission to special care baby unit Preterm delivery Perinatal mortality Caesarean section Caesarean section Gestation at delivery Birth weight Apgar score Admission to neonatal unit Perinatal mortality Special care admission: (3 RCTs, n = 7477) Peto OR 0.99 95% CI 0.82 to 1.19 Preterm delivery < 37 weeks of gestation: (3 RCTs, n = 9359) Peto OR 1.09, 95% CI 0.89 to 1.33 Perinatal mortality (excluding congenital abnormalities): (3 RCTs, n = 9359) Peto OR 1.10 95% CI 0.59 to 2.07 Emergency caesarean section: (2 RCTs, n = 5461) Peto OR 1.02, 95% CI 0.84 to 1.23 Emergency caesarean section: (1 RCT, n = 2834) Peto OR 0.80, 95% CI 0.62 to 1.05 Gestation at delivery: (mean, SD) (1 RCT, n = 2834) WMD 0.100, 95% CI 1.205 to 1.005 Birth weight (mean, SD) (1 RCT, n = 2834): WMD 25.000, 95% CI 67.526 to 17.526 Apgar score < 5 at 7 minutes (1 RCT, n = 2834) Peto OR 0.76, 95% CI 0.46 to 1.27 Admission to neonatal unit (1 RCT, n = Study type EL
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NATIONALE RICHTLIJN PRENATALE ZORG:
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Nationale richtlijn prenatale zorg:
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KCE reports vol. 6A Prenatale zorg
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KCE reports 1. Effectiviteit en kos
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