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<strong>KCE</strong> reports vol. 6A Prenatale zorg 192 Study Ref Population Intervention Outcomes Results Comments Study type EL Whitlow et al., 1999 4 [300] 6634 women carrying 6443 live fetuses in London, England ultrasound (n = 4619) Ultrasound scan at 12 to 13 weeks of gestation Perinatal mortality (per 1000) Screening sensitivity for major malformations Detection rate for major structural abnormalities Sensitivity: 40% vs. 27.7% Sensitivity per hospital: 75% (9/12 cases detected) and 35% (9/26 cases detected) Overall detection rate: 59% (37/63), 95% CI 46.5 to 72.4: CNS 84% (16/19) Face 0% (0/2) Neck 100% (13/13) Cardiac 40% (4/10) Pulmonary 33% (1/3) Gastrointestinal 100% (7/7) Urinary tract 60% (3/5) Skeletal 0% (0/7) CSS 3
<strong>KCE</strong> reports vol. 6A Prenatale zorg 193 1. c. Ultrasound in the third trimester Study Ref Population Intervention Outcomes Results Comments Study type EL Bricker and 27 7 controlled Assessment of Obstetric No difference in Lack of data with SR 1a Neilson, 1999 trials recruiting the effects on practice antenatal , regard to long 25,036 pregnant obstetric practice obstetric and term substantive women and pregnancy Pregnancy neonatal outcomes such and outcome of outcome intervention or as routine late morbidity in neurodevelopme pregnancy screened versus nt ultrasound, control groups and with regard defined as to maternal greater than 24 Routine late psychological weeks gestation, pregnancy effects in women with ultrasound was either unselected not associated Reproducibility or low risk with of the results of pregnancies improvements in the one trial that overall perinatal assessed mortality Placental grading as an adjunct third trimester examination scan was associated with a significant reduction in the stillbirth rate ( in the 1 trial that assessed it) placental grading is uncertain
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KCE reports 1. Effectiviteit en kos
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