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<strong>KCE</strong> reports vol. 6A Prenatale zorg 184 Study Ref Population Intervention Outcomes Results to 3.17 Comment s Goldenberg et al., 1996 4 [545] 2929 women from 10 centres in the USA from 1992 to 1994 Measurement of fetal fibronectin in the cervix and vagina every two weeks from 22 to 24 weeks of gestation to 30 weeks of gestation as a screening test for preterm birth Sensitivity and specificity (positive test defined as fetal fibronectin greater than or equal to 50 ng/mL) at 19 weeks or more, 9.7% vs. 3.7%, RR 2.63, 95% CI 1.75 to 3.94 Sensitivity and specificity for birth at 34 weeks or earlier for fetal fibronection measurement at: 24 weeks, 23% (95% CI 16 to 31) and 97% 26 weeks, 22% (95% CI 14 to 32) and 97% 28 weeks, 20% (95% CI 11 to 30) and 97% 30 weeks, 29% (95% CI 18 to 41) and 96% Sensitivity of fibronectin at 22 to 24 weeks for preterm birth occurring at: 24 to 27 weeks, 63% (95% CI 38 to 84) 24 to 29 weeks, 54% (95% CI 28 to 66) 24 to 31 weeks, 38% (95% CI 25 to 53) Study type EL CH 2a
<strong>KCE</strong> reports vol. 6A Prenatale zorg 185 Study Ref Population Intervention Outcomes Results Comment s 24 to 34 weeks, 21% (95% CI 14 to 29) 24 to 36 weeks, 10% (95% CI 7 to 14) Study type EL
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KCE reports 1. Effectiviteit en kos
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