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KCE reports vol. 6A Prenatale zorg 184
Study Ref Population Intervention Outcomes Results
to 3.17
Comment
s
Goldenberg
et al., 1996
4 [545] 2929 women from 10
centres in the USA
from 1992 to 1994
Measurement of fetal fibronectin in the
cervix and vagina every two weeks from
22 to 24 weeks of gestation to 30
weeks of gestation as a screening test
for preterm birth
Sensitivity and specificity
(positive test defined as
fetal fibronectin greater
than or equal to 50
ng/mL)
at 19 weeks or more, 9.7%
vs. 3.7%, RR 2.63, 95% CI
1.75 to 3.94
Sensitivity and specificity for
birth at 34 weeks or earlier
for fetal fibronection
measurement at:
24 weeks, 23% (95%
CI 16 to 31) and 97%
26 weeks, 22% (95%
CI 14 to 32) and 97%
28 weeks, 20% (95%
CI 11 to 30) and 97%
30 weeks, 29% (95%
CI 18 to 41) and 96%
Sensitivity of fibronectin at
22 to 24 weeks for preterm
birth occurring at:
24 to 27 weeks, 63%
(95% CI 38 to 84)
24 to 29 weeks, 54%
(95% CI 28 to 66)
24 to 31 weeks, 38%
(95% CI 25 to 53)
Study
type
EL
CH 2a