Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 183
Study Ref Population Intervention Outcomes Results Comments Study
type
the results of the determine posttest
300 mg/24- hour
diagnostic test of probabilities
proteinuria at
interest were
the 1+ or greater
compared with
the results of a
reference
threshold
standard
Pooled negative
likelihood ratio 0.6 (95%CI 0.45 to 0.8)
Population of
for predicting
pregnant women
300 mg/24- hour
proteinuria at
the 1+ or greater
threshold
3. c. Preterm birth: measurement of fetal fibronectin
What is the sensitivity and specificity of a fetal fibronectin measurement?
Study Ref Population Intervention Outcomes Results Comment
Goldenberg
et al., 2000
4 [544] 10456 women with
singleton pregnancies
in the USA from 1995
to 1998
Measurement of fetal fibronectin values
at 8 to 22 weeks
Preterm birth (greater
than or equal to 13
weeks and less than 35
weeks)
Comparing fetal fibronection
level in greater than or equal
to 90th percentile with less
than 90th percentile:
at 13 to 14 weeks, 12.1% vs.
5.5%, RR 2.19, 95% CI 1.27
to 3.80
at 15 to 16 weeks, 13.5% vs.
4.4%, RR 3.06, 95% CI 1.73
to 5.41
at 17 to 18 weeks, 5.9% vs.
3.8%, RR 1.54, 95% CI 0.74
s
EL
Study
type
EL
CH 2b