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<strong>KCE</strong> reports vol. 6A Prenatale zorg 180 Study Ref Population Intervention Outcomes Results Comments Study type 3. b. Pre-eclampsia Risk factors for the development of diabetes Prepregnancy weight was significantly higher in the new compared with the old cohort: 26.0 (22.5-30.8) vs. 22.9 kg/m 2 (20.2-28.0) New-cohort membership, prepregnancy overweight (BMI º 25kg/m 2 ), and IGT postpartum were identified as independent predictors of diabetes. Urine-dipstick: proteinuria Study Ref Population Intervention Outcomes Results Comments Study Barton et al., 2001 4 [515] 748 women with a singleton pregnancy with hypertension in the USA from 1995 to 1998 Women from 24 to 35 weeks of gestation with no proteinuria by dipstick (0 or trace) at admission to study monitored for progression to proteinuria Progression to proteinuria Progression to severe preeclampsie Rate of progression to proteinuria by gestational age at enrolment Incidence of SGA babies Proteinuria developed in 343/748 (46%)women Severe pre-eclampsia developed in 72/748 (9.6%) women Rate of progression greater in women enrolled at less than 30 weeks compared with 34 to 35 weeks, p = 0.008 SGA in women with proteinuria versus Gestational hypertension defined as maternal blood pressure greater than or equal to 140 mmHg systolic or 90 mmHg diastolic. Proteinuria defined as greater than or equal to 1+ (by dipstick) on at least two occasions. Severe pre-eclampsia defined as either 1) severe hypertension (160/110 mmHg on 2 occasions), 2) mild hypertension with severe proteinuria (greater than or equal to 3+) or 3) development of thrombocytopenia EL EL type CSS 3
<strong>KCE</strong> reports vol. 6A Prenatale zorg 181 Study Ref Population Intervention Outcomes Results hypertension alone: 24.8% vs. 13.8%, p < 0.001 Comments Study type EL Page and 4 [516b] 12,954 singleton Levels of mean arterial Fetal mortality In third trimester: CH 2b Christianso pregnancies in pressure in the middle (121 to and increase in fetal deaths n, California, USA 180 days) and third (after 180 morbidity and morbidity above 95 1976 from 1959 to days) trimester assessed in mmHg 1967 relation to pregnancy Stillbirth outcomes in women with or rate/1000 Middle trimester, without proteinuria stillbirth rate: Perinatal In white women (n = death/1000 10,074): without proteinuria and
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NATIONALE RICHTLIJN PRENATALE ZORG:
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Nationale richtlijn prenatale zorg:
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KCE reports vol. 6A Prenatale zorg
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KCE reports 1. Effectiviteit en kos
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