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KCE reports vol. 6A Prenatale zorg 180
Study Ref Population Intervention Outcomes Results Comments Study
type
3. b. Pre-eclampsia
Risk factors for the
development of
diabetes
Prepregnancy weight was
significantly higher in the new
compared with the old cohort:
26.0 (22.5-30.8) vs. 22.9 kg/m 2
(20.2-28.0)
New-cohort membership,
prepregnancy overweight (BMI
º 25kg/m 2 ), and IGT postpartum
were identified as independent
predictors of diabetes.
Urine-dipstick: proteinuria
Study Ref Population Intervention Outcomes Results Comments Study
Barton et
al.,
2001
4 [515] 748 women with a
singleton
pregnancy with
hypertension in
the USA from
1995 to 1998
Women from 24 to 35 weeks
of gestation with no
proteinuria by dipstick (0 or
trace) at admission to study
monitored for progression to
proteinuria
Progression to
proteinuria
Progression to
severe preeclampsie
Rate of
progression to
proteinuria by
gestational age at
enrolment
Incidence of SGA
babies
Proteinuria developed in
343/748 (46%)women
Severe pre-eclampsia
developed in 72/748
(9.6%) women
Rate of progression
greater in women
enrolled at less than 30
weeks compared with
34 to 35 weeks, p =
0.008
SGA in women with
proteinuria versus
Gestational hypertension defined as
maternal blood pressure greater than
or equal to 140 mmHg systolic or 90
mmHg diastolic.
Proteinuria defined as greater than or
equal to 1+ (by dipstick) on at least
two occasions.
Severe pre-eclampsia defined as either
1) severe hypertension (160/110
mmHg on 2 occasions), 2) mild
hypertension with severe proteinuria
(greater than or equal to 3+) or 3)
development of thrombocytopenia
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type
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