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KCE reports vol. 6A Prenatale zorg 179
Study Ref Population Intervention Outcomes Results Comments Study
type
Goldberg et
al., 1986
Lauenborg
et al., 2004
4 [508] 58 pregnant women
and 58 controls from
an antenatal diabetes
clinic in the USA
from 1979 to 1984
89 241 Danish women
with diet-treated
GDM during 1978-
1985 (old cohort,
also followed up
around 1990)
512 Danish women
with diet-treated
GDM during 1987-
1996 (new cohort)
Home glucose monitoring
vs. controls
Insulin therapy begun in
subjects of either group if
glucose values were > 95
mg/dl or if postprandial
values were > 120 mg/dl
481 (63.9%) women
underwent a 2-h, 75 g
OGTT (WHO
classification) or
Intravenous glucagon test
supplemented by
measurement by GAD
antibodies in 2000-2002
Historical data from indexpregnancy
and
anthropometrical
measurements were
collected
Use of insulin
Neonatal
outcomes
Caesarean section
The long-term
incidence of
diabetes among
Danish women
with previous diettreated
GDM
Changes in the
incidence of
diabetes and
overweight during
the last decades
among women
with previous diettreated
GDM
Fetal macrosomia: 12.5% vs.
12.7% of
newborn in each region
Use of insulin: 29 (50%) vs. 12
(21%), p < 0.01
Birth weight: 3231 µ 561 vs.
3597 µ 721, p < 0.002
Macrosomia (º 4000 g): 5 (9%)
vs. 14 (24%), p < 0.05
Large for gestational age: 7
(12%) vs. 24 (41%), p < 0.005
Caesarean section: 32% vs.
25%, NS
Prevalence of diabetes and
impaired glucose tolerance
(IGT)/ impaired fasting glucose:
40.0% and 27.0% respectively
In the new cohort: 40.9%
diabetes
In the old cohort at the 1990
follow-up: 18.3% diabetes. (p<
0.0005)
EL
CCS 3
CH 2b