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KCE reports vol. 6A Prenatale zorg 168
Study Ref Populatio
n
Intervention Outcome
s
3. Screening for clinical conditions
3. a. Gestational diabetes mellitus
Results Comments Study
type
- Daily suppressive acyclovir in the last 4 weeks of pregnancy may prevent
recurrences of genital herpes at term. (1b)
- For women presenting with recurrent genital herpes lesions at the onset
of labour, the risks to the mother of caesarean section are small and
should be set against the risks to the mother of caesarean section. (3)
Recommended prevention of acquisition of genital herpes infection during
pregnancy:
- All women should be asked at their first antenatal visit if they or their
male partner ever had genital herpes. Female partners of men with genital
herpes, who themselves give no history of genital herpes, should be
advised about reducing their risk of acquiring this infection. (4)
What are the maternal and perinatal outcomes associated with gestational diabetes?
Study Ref Population Intervention Outcomes Results Comments Study
Mestman et
al., 1972
OÊSullivan et
al., 1973
4 [485] 360 pregnant women in the
USA
4 [487] 187 GDM patients and 259
negative control patients in
Boston, USA from 1962 to
All had GTT and prednisolone
GTT. All women followed up for 5
years
Abnormal GTT at
pregnancy
Abnormal GTT five
year after pregnancy
GDM diagnosed with GTT Perinatal mortality
(28th week of
gestation to 14 days
During pregnancy: 51/360 with
elevated fasting blood sugar; 181/360
abnormal GTT; 90/360 positive
PGTT; 38/360 normal
5 years later: with elevated fasting
blood sugar, 17/51 had abnormal
GTT; with abnormal GTT, 59/181
still had abnormal GTT; with positive
PGTT, 12/90 had abnormal GTT;
0/38 normal had abnormal GTT
GDM: 12/187 (6.4%) babies died;
normal
GTT: 4/259 (1.5%) babies died, p <
EL
EL
type
CH 2b
CCS 3