Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 167
Study Ref Population Interventio
n
from 3000
to 7166
sera.
Outcomes Results Comments Study
type
Herpes simplex
Study Ref Populatio Intervention Outcome Results Comments Study EL
n
s
type
RCOG, 25 The risks on transmission and consecutive neonatal herpes are greatest when
GL EL
2002
the mother acquires a new infection during late pregnancy. Most of these
adopted
maternal infections are asymptomatic or unrecognised and it may be difficult
from the
to distinguish clinically between recurrent and primary HSV infections.
guideline
and noted
Type specific HSV serology has only recently become available and its use and
between
management has not been fully evaluated.
( ) in the
results-
Recommended management of women presenting with a first episode of
genital herpes during pregnancy:
column
- Management of the woman should be in line with her clinical condition,
which will often involve a five day course of oral acyclovir in standard
doses (D-GPP)
- Daily suppressive acyclovir in the last suppressive acyclovir in the last
four weeks of pregnancy may prevent genital herpes recurrences at term
(1b)
- Caesarean section is recommended for all women presenting with firstepisode
genital herpes lesions at the time of delivery. For women who
present with first-episode genital herpes lesions within 6 weeks of the
expected date of delivery or onset of preterm labour, elective caesarean
may be considered at term, or as indicated, and the paediatricians should
be informed. (3)
Recommended management of women presenting with a recurrent episode
of genital herpes during pregnancy:
EL