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KCE reports vol. 6A Prenatale zorg 164
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
cases of maternal seroconversion pregnancy losses for each case avoided
Foulon 85 144 Assessment of the association between
Incidence of congenital infection: 64/144 Treatment CH 2b
et al.,
women transmission and appearance of sequelae as
(44%)
differs
1999
with a function of the following parameters:
- transmission was only predicted by
toxoplasm estimated gestational age at infection,
gestational age at which maternal
a serocon- administration of antibiotic therapy, duration
infection occurred (p< .0001)
version of antibiotic therapy, time lapse between
during infection and the start of antibiotic therapy
Incidence of sequelae: 19/144 (13%)
pregnancy,
- the absence of sequelae was predicted
recruited
by administration of antibiotics (p=.026,
in 5
different
OR 0.30, 95% CI 0.104-0.863)
toxoplasm
Incidence of severe sequelae: 9/144 (6%)
a
- the absence of severe sequelae was
reference
predicted by administration of antibiotics
centers
(p=.007, OR 0.14, 95 CI 0.036-0.584)
2. l. Varicella
Study Ref Populatio
RCOG,
2001
The sooner antibiotics were given after
infection the less frequently sequelae were
seen
Interventio Outcome Results Comments Study EL
n n s
type
24 90% of the antenatal population are seropositive for VZV IgG
GL EL
adopted
Primary VZV infection is uncommon in pregnancy: estimated prevalence: 3/1000.
from the
Maternal risks of varicella in pregnancy: pneumonia (10%), hepatitis, encephalitis,
guideline
mortality
=3
Fetal and neonatal risks of varicella before 20 weeks of gestation: fetal varicella
syndrome