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KCE reports vol. 6A Prenatale zorg 158
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Foulon et 4 144 women with Fetal infection detected by Overall transmission Overall transmission:
Analysis on CS 3
al., 1999 [473] confirmed
cordocentesis, amniocentesis Risk of congenital 44% (64/144) gave birth to an infected (n = 64)
toxoplasmosis infection or both
infection by time of infected infant (antibiotics made no vs. uninfected
from 5 European Antibiotic treatment of maternal infection difference in transmission rate, p = infant not
centres
119/144 affected women
Congenital toxoplasmosis
Clinical signs in infant 0.7)
presented
determined by cord and
Risk of congenital infection by time
neonatal blood samples.
of maternal infection:
Infants followed-up to 1 year
At 6 to 10 weeks of gestation: 21%;
of age
11 to 15 weeks: 19%; 16 to 20
weeks: 23%; 21 to 25 weeks: 60%;
26 to 30 weeks: 65%; 31 to 35
weeks: 93%
Lappalainen
et al., 1995
Lebech et
al., 1999
4
[622]
4
[469]
16,733 pregnant
women in Finland from
1988 to 1989
99,246 consecutive
deliveries in Denmark
from 1992 to 1996
Screening for primary
toxoplasmosis in mother
Follow-up of 37 liveborn
infected children
Mothers screened at delivery
for toxoplasma infection and
infants of positive mothers
followed for 12 months after
Mothers with
toxoplasmosis
Annual incidence of
congenital
toxoplasmosis
Prevalence of
toxoplasma infection
in infants
Clinical signs in infant:
4 fetuses aborted; therefore, from
140
infants, 14% (19/140) either died in
utero, had neurological
abnormalities, hydroencephalus,
cerebral calcifications, and/or
choroidal scars with or without
visual impairment
42 mothers with toxoplasmosis
infection
4 infants with confirmed congenital
toxoplasma infection; 0.3/1000 live
born children per year
0.3 per 1000 This study
represented
about one-third
of all deliveries
CS 3
CS 3