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KCE reports vol. 6A Prenatale zorg 157
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Pratlong et 4 286 pregnant women Detection of fetal
Risk of congenital 18% (52/286) overall; 11% (17/155)
CS 3
al., 1996 [471] infected with
abnormalities by ultrasound infection by time of to 7 to 15 weeks; 26% (28/109) at
toxoplasmosis between and of toxoplasma in amniotic maternal infection 16 to 28 weeks ; 32% (7/22) at 29
7 and 34 weeks of
gestation in France
from 1985 to 1993
fluid and in fetal blood
to 34 weeks
Dunn et al., 4 603 confirmed Data collected from routinely Pregnancy outcome Planned termination: 5 women; Three women CS 3
1999 [472] maternal toxoplasmosis collected information in Risk of congenital miscarriage: 3 women; stillbirth: 3 gave birth to
infections in France medical records
infection by time of women; live birth: 591 women; twins; data
from 1987 to
maternal infection unknown: 1 woman
reported on
1995
Diagnosis of fetal infection Clinical outcome of Congenital infection confirmed in firstborn twin
based on cordocentesis or liveborn infants with 153 infants; excluded in 396 infants; only
amniocentesis with clinical toxoplasmosis (n = 42 infants lost to follow-up
examination after birth at 2, 153)
Overall transmission rate among
5, 8 and 12 months and Risk of development liveborn infants: 26% (153/591); 6%
annually thereafter for a of clinical signs in (95% CI 3 to 9) at 13 weeks of
median of 4.5 years
infant by time of gestation; 40% (95% CI 33 to 47) at
maternal infection 26 weeks of gestation; 72% (95% CI
60 to 81) at 36 weeks of gestation
27% (41/153) of infected infants had
chorioretinal lesions (n = 33),
intracranial calcification (n = 14)
and/or hydrocephaly (n=2)
Risk of clinical sign at 13 weeks:
61% (95% CI 34% to 85%); at 26
weeks: 25% (95% CI 18% to 33%);
at 36 weeks 9% (95% CI 4% to
17%)