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KCE reports vol. 6A Prenatale zorg 156
What is the prevalence of toxoplasma susceptibility in pregnant women, what is the incidence of seroconversion or primary infection during
pregnancy and what is the incidence of congenital toxoplasmosis in Belgium?
Study Ref Population Intervention Outcomes Results Commen Study EL
ts type
Foulon et 21 2986 pregnant women, patient at HA test and indirect fluorescent antibodytest at Susceptibility 47% (1403)
CH 2b
al., 1984 a hospital in Brussels between first prenatal visit
susceptible
1979 and 1982
Seroconversio
In case of negative serology:
n
20 of the initially
- Retest every 6 weeks in case of negative
susceptible women
serology
seroconverted during
- Cord blood sample at delivery
pregnancy
Naessens
et al.,
2003
In case of seroconversion or high initial
toxoplasma antibody titres:
- Cord blood and placental tissue to isolate
the parasite
- Clinical follow-up of the infant and serial
blood samples up to 11 months of age
22 N/A N/A Estimated
incidence of
primary
infection in
pregnancy
Estimated
incidence of
congenital
toxoplasmosis
8.5/1000
2/1000
RV 4
What is the prevalence of neonatal toxoplasmosis infection and what are its consequences?
Study Ref Population Intervention Outcomes Results Comments Study
type
EL