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KCE reports vol. 6A Prenatale zorg 154
Study Ref Population Intervention Outcomes Results Comments Study
type
September 1997 to Serum samples also tested at birth weight) in outcomes between
November 1999 (556 reference laboratory by TPHA. seronegative vs. the two groups: 17.3
RPR positive and 1132 FTA assay performed on sera that women treated for vs. 15.2 for all
RPR negative) gave conflicting results from RPR
and TPHA
syphilis
outcomes (p = 0.86)
No significant
difference in mean
birth weight
between the two
groups (p = 0.24)
Is it cost effective to undertake universal screening for syphilis infection in pregnant women in the UK?
Study Ref Population Intervention Outcomes Results Comments Study
Conner
et al.,
2000
4
[602]
Data provided by 8
laboratories that
performed a total of
169,140 antenatal
screening tests for
syphilis in one year,
approximately one-fifth
of the number of
antenatal tests
conducted in the UK
Estimation of costs based
on the assumption that 40
women a year are
detected and treated
through antenatal
screening and that the
number of screening tests
performed equalled the
number of live births in
the UK (annual births
750,000)
Cost of screening
in the UK based
on the cost of
screening tests,
treatment, and
follow-up of
infected women
and their infants
Costs of screening estimated to
be
£672,366 (£161,849 to
£2,306,382), or £0.90 per
pregnancy screened
NNT = 18,602 women
screened to detect one woman
who needs treatment for
syphilis and a maximum of
55,713 women need to be
screened to prevent one case of
congenital syphilis. This is the
equivalent of £16,670 for each
woman treated for syphilis, or
£49,928 for each case of
congenital syphilis prevented
Targeted screening of high risk
groups would detect 70% of
cases but would be practically
difficult. Costs for targeted
screening strategies are also
presented for women in the
Thames region, pregnant
women in nonwhites ethnic
groups and women born outside
the UK. Targeting or stopping
screening would save relatively
little money.
type
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