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KCE reports vol. 6A Prenatale zorg 152
Study Ref Populatio
n
PHLS CDSC and
PHLS Syphilis
Working Group,
1998
4 [453] N/A Treponemal tests:
TPHA, FTA-Abs,
EIAs
Intervention Outcome Results Comments Study
s
type
testing present. If TPHA is used for screening, then EIA can be
used as the confirmatory test
Non-treponemal
tests: RPR, VDRL
Further evaluation of immunoblotting as confirmatory test
is needed
EIAs: over 98% sensitive, over 99% specific
All treponemal tests sensitive at all stages of syphilis
(except early primary syphilis) 98% and 98% to 99% specific
May result in false negatives, particularly in very early or
late syphilis, in patients with reinfection or who are HIV
positive
Predictive value of these tests is poor when used alone in
low-prevalence populations
This information is
from a report to the
UK National Screening
Committee
(unpublished)
Wat are the available interventions for managing women who are infected with syphilis?
Study Ref Population Intervention Outcomes Results Comments Study
Walker,
2001
Hashisaki
et al., 1983
4 [462] Pregnant women with a
confirmed diagnosis of
syphilis, with and without
concomitant HIV infection
Cochrane review, most
recent update 2001
4 [465] Pregnant woman with
history of allergy to
penicillin diagnosed with
primary syphilis
To determine the
most effective
antibiotic treatment
regimen of syphilis
Two successive
course of
erythromycin therapy
Maternal resolution of
clinical symptoms,
miscarriage, stillbirth,
neonatal deaths, and
congenital syphilis
Efficacy of erythromycin
treatment
No RCTs identified Available evidence is
insufficient to
determine the optimal
penicillin regimen
Failure to cure infection.
Subsequent successful
treatment with penicillin
after desensitisation
EL
SR 4
EL
type
SR 1a
CR 3