Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 151
Study Ref Population Intervention Outcomes Results Comments Study
type
All cases 1.2 (0.2 to 9.4)
Congenitally Non- 1
malformation syphilitic
clinically detected New 4.9 (1.3 to 18.5)
before discharge cases
All cases 1.3 (0.3 to 5.7)
What is the prevalence of congenitally acquired syphilis infection and what are the consequences of infection?
Study Ref Population Intervention Outcomes Results Comments Study
PHLS CDSC
and PHLS
Syphilis
Working
Group, 1998
4 [453] Children under 2
years old in England
and Wales between
1988 and 1995
Children identified
through the British
Paediatric
Surveillance
Unit
Surveillance of
genitourinary
medicine clinic
data
Surveillance
programme from
June 1993 to July
1997
Cases of syphilis
in children
Cases of syphilis
in children as
defined by US
CDC
Annual
incidence
34 cases of early congenital
syphilis reported from
genitourinary medicine clinics; 2
more cases reported in 1996
9 reported with presumptive
syphilis and 8 possible cases of
congenital syphilis. No definite
cases reported by paediatricians
in the UK
Rate of 0.06/1000 live births
Possible that some children with
congenital syphilis were being
treated outside genitourinary
medicine clinic system; i.e., these
estimates are conservative
EL
EL
type
SV 3
What are the diagnostic tests available for detection of syphilis infection and how do they compare in terms of specificity, sensitivity and
cost-effectiveness?
Study Ref Populatio Intervention Outcome Results Comments Study EL
n
s
type
Egglestone and 4 [449] N/A Algorithm for
FTA-abs still generally considered to be the gold standard,
SSW 4
Turner, 2000
treponemal
but TPHA is more sensitive, except in the third and fourth
antibody screening
weeks of infection. TPHA is also more specific. Therefore
and confirmatory
most appropriate for confirming reactive EIA results at