Download het volledig rapport (302 p.) - KCE

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<strong>KCE</strong> reports vol. 6A Prenatale zorg 150 Study Ref Population Intervention Outcomes Results Comments Study type Neonatal death Not treated 1 Treated 1.2 (0.2 to 8.8) Congenitally Not 1 malformation treated clinically detected Treated before discharge 1.3 (0.3 to 5.5) The effect of syphilis acquired during pregnancy an of syphilis during the pregnancy period Preterm
<strong>KCE</strong> reports vol. 6A Prenatale zorg 151 Study Ref Population Intervention Outcomes Results Comments Study type All cases 1.2 (0.2 to 9.4) Congenitally Non- 1 malformation syphilitic clinically detected New 4.9 (1.3 to 18.5) before discharge cases All cases 1.3 (0.3 to 5.7) What is the prevalence of congenitally acquired syphilis infection and what are the consequences of infection? Study Ref Population Intervention Outcomes Results Comments Study PHLS CDSC and PHLS Syphilis Working Group, 1998 4 [453] Children under 2 years old in England and Wales between 1988 and 1995 Children identified through the British Paediatric Surveillance Unit Surveillance of genitourinary medicine clinic data Surveillance programme from June 1993 to July 1997 Cases of syphilis in children Cases of syphilis in children as defined by US CDC Annual incidence 34 cases of early congenital syphilis reported from genitourinary medicine clinics; 2 more cases reported in 1996 9 reported with presumptive syphilis and 8 possible cases of congenital syphilis. No definite cases reported by paediatricians in the UK Rate of 0.06/1000 live births Possible that some children with congenital syphilis were being treated outside genitourinary medicine clinic system; i.e., these estimates are conservative EL EL type SV 3 What are the diagnostic tests available for detection of syphilis infection and how do they compare in terms of specificity, sensitivity and cost-effectiveness? Study Ref Populatio Intervention Outcome Results Comments Study EL n s type Egglestone and 4 [449] N/A Algorithm for FTA-abs still generally considered to be the gold standard, SSW 4 Turner, 2000 treponemal but TPHA is more sensitive, except in the third and fourth antibody screening weeks of infection. TPHA is also more specific. Therefore and confirmatory most appropriate for confirming reactive EIA results at
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NATIONALE RICHTLIJN PRENATALE ZORG:
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Nationale richtlijn prenatale zorg:
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KCE reports 1. Effectiviteit en kos
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