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KCE reports vol. 6A Prenatale zorg 148
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
8.5% died in neonatal
period (vs. 2.2%)
2% live birth to
infected infant (vs.
0%)
77% chance of birth
to healthy, uninfected
infant (vs. 95%)
reported
Fiumara et 4 1005 pregnant women Syphilis diagnosis Pregnancy outcomes 24 had syphilis, 13 of which
CS 3
al., 1952 [458] admitted in labour in occurred either before
were old and treated cases,
Boston, USA in 1951 pregnancy, antenatally Preterm birth defined as 11 diagnosed antenatally or
or after delivery gestational age less than 37
weeks
after delivery
None resulted in congenital
syphilis
Rotchford et
al., 2000
4
[459]
1783 pregnant women
from 12 clinics in South
Africa screened for
syphilis at first antenatal
care visit between June
and Oct 1998
Adequate (n = 108) vs.
inadequate (n = 50;
includes n = 30 no
treatment) with
penicillin
Inadequate = less than
2 doses
Adequate = at least 2
doses
Perinatal outcome in mother
(because data on how many
live births were twin
pregnancies not available)
6/24 preterm births (25%)
compared with 113/981
(11.5%) among women
without syphilis (NS)
Of 1783 women, 158
tested positive for syphilis,
data on pregnancy outcome
available for 142 women
17 perinatal deaths among
15 women; stillbirths
among 6 women; 9 women
had early neonatal deaths
Of 43 inadequately treated
women for whom
pregnancy outcome was
Baseline findings from
RCT
Treatment: 3 weekly
intramuscular
injections of 2.4 megaunits
of benzathine
penicillin (as per DoH
South Africa)
Perinatal death
defined as stillbirth or
early neonatal death
CS 3