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KCE reports vol. 6A Prenatale zorg 147
Study Ref Population Intervention Outcomes Results Comments Study
type
overall prevalence - previous stillbirth (OR 2.6, 95% CI
1.6 to 4.0)
Risk factors for incidence:
- age34 (OR= 1.6, 95% CI 1.1 to
2.1)
- previous stillbirth (OR= 2.5, 95%
CI 1.6 to 3.8)
What are the maternal and perinatal outcomes associated with syphilis infection in pregnancy?
Study Ref Population Intervention Outcomes Results Comments Study
Ingraham,
1951
4
[455]
1063 women with syphilis
treated with penicillin and
three control groups: 302
women with untreated
syphilis, 594 women with
bismuth and arsenical
treatment of syphilis and
10,323 women without
syphilis in the USA in the
1940s
Comparison of
pregnancy outcomes
between the penicillin
treated syphilis and
control groups
Effect of untreated syphilis
on pregnancy outcomes (n =
302) compared with
nonsyphilitic pregnancy (n =
10,232)
Early syphilis (n = 220):
25% stillborn (vs.
2.6%)
14% died in neonatal
period (vs. 2.2%)
41% live birth to
infected infant (vs.
0%)
20% live birth without
syphilis (vs. 95%)
Late syphilis (n = 82):
12% stillborn (vs.
2.6%)
Because penicillin
became widely
available in 1950s, no
prospective
observational studies
in developed countries
All differences
between the early
untreated group and
the treated group
were reported to be
significant but the level
of significance was not
EL
EL
type
CS 3