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KCE reports vol. 6A Prenatale zorg 146
Study Ref Population Intervention
women were
screened)
Outcomes Results Comments Study
type
Hurtig et al.,
1998
PHLS CDSC
and PHLS
Syphilis
Working
Group, 1998
Flowers and
Camilleri-
Ferrante, 1996
Lumbiganon,
2002
4
[620]
4
[453]
4
[452]
139 women treated for
syphilis during pregnancy
and 17 children meeting
the case definition of
congenital syphilis from
1994 to 1997, excluding
Scotland (n = 136)
139 women treated for
syphilis during pregnancy
and 17 children meeting
the case definition of
congenital syphilis from
1994 to 1997, excluding
Scotland (n = 136)
Pregnant women in East
Anglia identified by
screening
82 24,526 pregnant women.
Data missing in 257
women. 24,269 women
remain.
The population was
enrolled in a multicentre
RCT in clinics located in
Argentina, Cuba, Saudi
Arabia and Thailand.
National survey of
genitourinary
medicine specialists
and paediatricians;
surveillance
National survey of
genitourinary
medicine specialists
and paediatricians;
surveillance
Incidence of
syphilis detected in
pregnancy and
congenital syphilis
Minimum overall
prevalence of
women
considered to
need treatment
for syphilis in
pregnancy
Surveillance Positive screening
test for syphilis
Screening at the
first antenatal visit
and after delivery
Prevalence at first
antenatal visit
Incidence during
pregnancy
Overall prevalence
Risk factors for
initial prevalence,
incidence and
121 women were detected through
antenatal screening: 31 had confirmed
or probably congenitally transmissible
syphilis (30 excluding Scotland); NNT =
18,600 and 55,700 (maximum numbers)
to detect one woman needing
treatment and to prevent one case of
congenital syphilis, respectively
For England and Wales: 0.068 (95% CI
0.057 to 0.080) per 1,000 live births
Over the period
1994 to 1997, over 2
million women would
have been screened
as part of antenatal
care
Denominators
derived from routine
ONS birth statistics
4-8 per million pregnancies Estimated from 1991-
1995 out of an
estimated 130,000
Prevalence at first antenatal visit:
216/24,269 (0.9%)
Incidence during pregnancy: 78/20,320
(0.4%)
Overall prevalence: 294/20,536 (1.4%)
Risk factors for initial prevalence:
- age>34 (OR=1.6, 95% CI 1.1 to
2.1)
pregnancies screened
Possible bias because
of high numbers of
missing values in
Saudi Arabia
EL
CSS 3
CSS 3
SV 3
LS 3