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<strong>KCE</strong> reports vol. 6A Prenatale zorg 144 Study Ref Population Intervention Outcomes Results Comment s Pederson, population of 50,000 in Norway and benefit of rubella vaccination of various 1982 prognosis of congenital rubella in programmes (with goal of vaccination Based on cost/benefit ratios, net benefit unvaccinated population (n = 38 preventing rubella in programmes came from vaccination offered to all during epidemic period; n = 6 during pregnant women and women in puberty, supplemented with nonepidemic period) subsequent congenital offering vaccination to nonimmunised rubella syndrome) women after delivery and women at high risk of exposure If participation in vaccination programme < 100%, vaccination offered at two ages (e.g. childhood and puberty) gives best results in prevention of congenital cases What are the interventions for a susceptible woman who is exposed to rubella infection during pregnancy? Study Ref Population Intervention Outcome Results Comments Study EL s type Tookey, 4 There is no treatment to prevent or reduce mother-to-child Report provided by the REC 4 2002 [422] transmission of rubella once infection has been detected in UK pregnancy National Screening Committee working group 2. j. Syphilis What is the incidence of syphilis infection in Belgian women? Study Ref Population Interventio Outcomes Results Comments Study EL n type Surveillance network 71 Belgian ? Incidence of syphilis infection in Belgian women 3 Age of the population SV 4 of 69 sites population between October 2002 and January 2003 between 40 and 70 years Study type EL
<strong>KCE</strong> reports vol. 6A Prenatale zorg 145 Study Ref Population Interventio n Outcomes Results Comments Study type Participation to the network is voluntary What is the prevalence of syphilis infection in pregnant women? Study Ref Population Intervention Outcomes Results Comments Study Donders et al., 1997 65 1340 eligible women presenting for routine prenatal care at Gasthuisberg University Hospital in Leuven, Belgium during 1993 At the beginning of pregnancy a routine screening was offered in one single bloodtube for the following: - Anti-CMV IgG (1043 women were screened) - Anti-rubella IgG (1268 women were screened) - HbsAg (1278 women were screened) - Anti-HIV IgG (1057 women were screened) - Rapid Plasma reagent (RPR/ 1277 women were screened) - Anti- Toxoplasma IgG (1340 Prevalence of anti-CMV IgG: 16% at age 18 and 50% at age 40 (mean 28.3%) Deficient immunity against rubella: 15/1268 (1.2%) HBsAg carriership 0.23% No HIV infection detected Past infection with treponema pallidum occurred in 0.31% (RPR
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KCE reports 1. Effectiviteit en kos
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