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KCE reports vol. 6A Prenatale zorg 143
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Grillner 4 491 cases of rubella in Consequences of rubella Outcome of rubella infected 101 pregnancies infected
CH 2b
et al., [428] pregnant women from during pregnancy with pregnancies
from 17 to 24 weeks of
1983
1978 to 1980 and 118 special reference to
gestation; all except one
children followed up at age infection during 17th to Intrauterine transmission of resulted in liveborn infant
20 months, 4 years or 7 24th weeks of gestation rubella
years, in Sweden
A decline in rate of
Cases identified by Rubella defects
infection from weeks 9 to
surveillance and
16 (57% to 70%) to weeks
outcome determined by
17 to 20 (22%) and weeks
survey
21 to 24 (17%)
Morgan-
Capner
et al.,
1985
CDC
2001
4
[429]
4
[430]
7 pregnant women with
asymptomatic rubella
reinfection in early
pregnancy
680 Live births from
susceptible mothers in
the UK, USA, Germany
and Sweden
Reports of 7 cases Identification of rubella
specific antibody (IgM) in
infants or products of
Inadvertent rubella
vaccination with HPV-
77,
Cendehill or RA 27/3 at
3
months before or during
pregnancy
conception
Congenital rubella syndrome No infant born with
congenital rubella
syndrome
From 1 to 16 weeks of
gestation, 10% to 40% of
surviving children had
rubella defects compared
with 0% to 2% of children
whose mothers were
infected
None detected CS 3
SV 3
Is it cost effective to screen pregnant women for rubella immunity?
Study Ref Population Intervention Outcomes Results Comment Study EL
s type
Stray- 4 [619] Model based on annual pregnant Modelling to assess cost Comparison All strategies were cost effective EE 3