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KCE reports vol. 6A Prenatale zorg 142
Study Ref Population Intervention Outcomes Results Comments Study
type
infections, 44 sera from follow-up of M reverse test
vaccinations, and 98 samples containing
Specificity:
potentially interfering analytes)
Roche: 100%
Abbott: 93.9%
Sorin: 82.7%
Does screening pregnant women for rubella immunity lead to improved maternal and perinatal outcomes?
Study Ref Population Intervention Outcomes Results Comments Study
Miller et
al., 1982
4
[425]
1016 pregnant women with
confirmed rubella infection
at different stages of
pregnancy from January
1976 to September 1978 in
England and Wales
Prospective follow-up of
infants to assess
consequences of
congenital infection
Pregnancy outcome; infection
status of infant; rubella defects
in seropositive (n = 102) vs.
seronegative (n = 133) infants
(congenital heart disease and
deafness); frequency of
congenital infection
Defects found in 20
children, all from
seropositive group
Incidence of other defects
(delayed motor
development, visual defects,
speech delay, etc) were not
found to be different
among the two groups of
infants
Congenital infection in first
12 weeks of pregnancy
among mothers with
symptoms was over 80%,
reduced to 25% at end of
second trimester
100% of infants infected
during first 11 weeks of
pregnancy had rubella
defects
Diagnosis of rubella
(in mothers) based
on 4-fold rise in
antibody titre or the
detection of specific
IgM
Infants defined as
infected if IgM
antibody present at
birth or persistence
of IgG after 1 year.
EL
EL
type
CH 2b