Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 141
Study
1999
Ref Population Intervention Outcomes Results Comments Study
type
What is the incidence of congenital rubella syndrome in babies in the UK?
Study Ref Population Intervention Outcomes Results Comments Study
Tookey,
2002
Miller et
al., 1997
4 [422] Annual average of 3
congenital rubella births and
4 rubella associated
terminations for 1996 to
2000
4 [423] Registered congenital
rubella births with
NCRSP or
terminations registered
with ONS
To monitor impact of
rubella immunisation
on congenital rubella
since 1971
Numbers of congenital rubella
infection births, number of
congenital rubella syndrome
births and number of
terminations for rubella disease
or contact
Just over 60 terminations for
rubella disease or contact in
pregnancy for England and
Wales for 1991 to 2000
(ONS 2001)
From 1996 to 2000:
congenital rubella infection: 1
case;
congenital rubella syndrome:
16 cases;
17 terminations
Data contained in a
report provided by the
UK National Screening
Committee working
group
type
EL
EL
4
SV 3
What are the diagnostic tests available for detection of rubella infection in pregnant women and how do they compare in terms of specificity,
sensitivity, and cost-effectiveness?
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Grageot- 4 [426] 852 sera (575 negative for anti-rubella virus Roche Rubella IgM eEIA Sensitivity Sensitivity:
TES 3
Keros and
IgM antibodies, 98 previously reactive sera, 28 recomb compared with and
Roche: 99.3%
Enders,
paired sera taken during the acute phase of Abbott IMx Rubella IgM specificity Abbott: 98.3%
1997
the disease, 9 sera from follow-up of primary test and Sorin ETI-RUBIK-
Sorin: 100%