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KCE reports vol. 6A Prenatale zorg 132
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Collaboration, diagnosis without
and analysis by intention to
1999
indication (or
By actual mode of delivery: treat and by actual mode of
contraindication) for
adjusted OR 0.4 (95% CI delivery
caesarean section
delivery in various
European countries,
including UK
0.2 to 0.9)
Mandelbrot et 4 2,834 singleton children Vaginal delivery vs. HIV infection status of Univariate analysis:
CH 2b
al., 1998 [410] born to mothers with caesarean section plus child
No zidovudine: RR
HIV infection in 85 zidovudine compared
1.0 (95% CI 0.6 to
perinatal centres in with vaginal delivery
1.6)
France from 1985 to vs. caesarean section
With zidovudine:
1996
without zidovudine
RR 0.1 (95% CI 0.0
to 0.8)
Multivariate analysis:
No zidovudine: OR
1.2 (95% CI 0.6 to
2.3)
With zidovudine:
OR 0.2 (95% CI 0.0
to 0.9)
Kind et al., 4 414 children of mothers Elective caesarean HIV infection status of Caesarean section +
NCC 3
1998 [617] in Switzerland known to section plus
children
zidovudine: 0/31 infected
be HIV infected from zidovudine vs.
(0%, 95% CI 0% to 11.0%)
1986 to 1 July 1996 caesarean section and
no zidovudine
Caesarean section + no
zidovudine: 7/86 infected
AND
(8%, 95% CI 3% to 16%)
Other modes of
delivery plus
zidovudine vs. other
modes of delivery and
Other delivery mode +
zidovudine: 4/24 infected
(17%, 95% CI 5% to 37%)