Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 130
Study Ref Population Intervention Outcomes Results Comments Study type EL
for endorsing a negative result and
confirming possible cases of HIV 2
infection
Samson
and
King, 1998
4
[413]
Literature review to
compile evidence-based
guidelines on HIV
screening in pregnancy
Recommendations on HIV
testing in pregnant women
The importance of requesting a
new specimen upon reactive
confirmation results to ensure
against procedural errors was also
demonstrated
Third generation EIA kits have
sensitivity 99.4%-100% and
specificity 99 100%
Combined EIA and Western blot
protocol has sensitivity 99% and
specificity 99.99%
These are
guidelines for
Canada
What are the interventions to decrease congenitally acquired HIV?
Study Ref Population Intervention Outcomes Results Comments Study
Brocklehurst
and Volmink,
2002
4
[416]
8 RCTs, various
countries, HIV infected,
pregnant women
Cochrane review
Most recent update 2002
Zidovudine
monotherapy vs.
placebo
Zidovudine vs.
zidovudine
Short short vs. long
long
Long short vs. long
long
HIV infection status of
child
Zidovudine vs. placebo,
4RCTs (n = 1379): OR 0.44
(95% CI 0.33 to 0.59)
Short short vs. long long,
1 RCT (n = 453): OR 2.46
(95% CI 1.15 to 5.27)
Long-short vs. long-long,
1RCT (n = 746): OR 0.66
(95% CI 0.35, 1.24)
Short long vs. long long, 1
In two studies, there was
uncertainty about whether
randomisation was
adequately concealed.
Another study was not blind
once the randomly allocated
packs were opened. The
remaining 5 studies were
double blind and randomised
EL
type
SR 1a