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KCE reports vol. 6A Prenatale zorg 123
Study Ref Population Intervention Outcomes Results
in all children, but no clinical
symptoms during follow-up
period
Comments Study
type
EL
Tovo et al., 19 104 children with Follow up from birth for a Viremia:
Viremia: HCV RNA:
LS 3
2001
perinatal HVC mean of 49 months to HCV RNA (PCR) - 54 persistently positive
infection in 22 centres outline the history of
- 44 occasionally positive
in 7 European perinatal hepatitis C virus Persistence of - 6 never detectable viremia
countries
infection
infection:
HCV RNA
Persistence of infection:
Anti HCV antibodies - 90% had evidence of
ALT values
ongoing infection at the
latest analysis
Antibody response
(ELISA)
Clinical features
ALT values
Immunoglobulin levels
Liver histology
Interferon therapy
Clinical features:
- Asymptomatic in all but 2
ALT values:
- Mean ALT values
substantially decrease after
the first 2 years of life
- 14 persistently normal
Liver histology:
- Signs of inflammation in all
20 patients who
underwent liver biopsy
What are the diagnostic tests available for detection of hepatitis C infection and how do they compare in terms of specificity and sensitivity?
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Colin et al., 77 10 evaluation studies To assess the sensitivity Sensitivity and Sensitivity:
High risk population SR of 3
2001
and specificity of third- specificity
- ELISA 3:
TES
generation serological
98.9% (95% CI: 94-100%) in
hepatitis C diagnostic tests
patients with chronic liver