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KCE reports vol. 6A Prenatale zorg 122
What is the prevalence of congenital Hepatitis C infection?
Study Ref Population Intervention Outcomes Results Comments Study
Ketzinel-
Gilad et al.,
2000
Tajiri et al.,
2001
20 22 HCV-infected
mothers and their 23
newborns in Israel
76 141 mothers with a
positive anti-HCV
antibodies test and
their 114 infants (drop
out of 33 infants)
Follow up from early after
birth by testing for the
presence of HCV
antibodies and HCV-RNA
Follow up of the infants
from birth for serum
alanine aminotransferase
activity, anti-HCV
antibodies and HCV RNA
at 0, 3, 6, 9, 12 months
and every year after
Mother-to-childtransmission
Transmission:
Anti-HCV antibodies
HCV RNA
Serum alanine
transferase
HCV antibodies:
- detected in the blood of all
newborns immediately
after birth
- dropped to low or
undetectable levels by the
age of 7 months
HCV-RNA:
- detected in the blood of 5
infants (22%)
- dropped to undetectable
levels by 6 months
Anti-HCV antibodies:
- 110/114 acquired
antibodies, undetectable
during the first year
HCV RNA
9/114 (7.8%)
- Vaginal delivery: 8/90 vs.
caesarean section: 1/24
(p=0.369)
- Breast-fed: 9/98 vs.
formula-fed: 0/16
(p=0.243)
- Maternal HCV viremia at
delivery: 9/9 (p=0.040)
- Maternal high viral load at
delivery: 9/9 (p=0.019)
Serum ALT: a general increase
EL
type
LS 3
LS 3