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KCE reports vol. 6A Prenatale zorg 117
Study Ref Population Intervention Outcomes Results
RR 22.3 (95% CI 11.5 to 43.2)
Comments Study
type
What are the diagnostic tests available for detection of hepatitis B viral infection and how do they compare in terms of sensitivity, specificity
and cost-effectiveness?
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Summers et 4 [394] All women attending the Serum collected at initial Number of women 136/15399 women found
CSS 3
al., 1987
antenatal clinic at a US prenatal visit
identified with risk factors to be HBsAg positive
hospital in New Orleans
(prevalence 0.88%)
from November 1983 Patients interviewed for
through October 1985 hepatitis B virus risk factors
No patient symptomatic
Chaita et
al., 1995
4 [395] 88 Thai women attending an
antenatal clinic with known
HBsAg status (44 HbsAg
positive)
Saliva and serum samples
were collected and then
analysed in Liverpool,
England, using ELISA to
detect HBsAg
Sensitivity and specificity
of screening for HBsAg in
saliva compared with
serum
54/108 (50%) pregnant
women demonstrated
risk factors
Sensitivity 92% (95% CI
84.5 to 99.5)
Specificity 86.8% (95% CI
76.0 to 97.6)
What are the interventions to reduce mother-to-child transmission of hepatitis B virus?
Study Ref Population Intervention Outcomes Results Comments Study
Sehgal et
al., 1992
4
[386]
109 HBsAg positive
mothers in India from
1987 through 1989
Group 1: HBV vaccine
within 24 hours of
birth and 2nd and 3rd
dose at 4 and 8 weeks,
respectively (n = 24)
Group 2: HBV vaccine
HBsAg carrier state in
infants at 6 months
HBV carrier rate:
Group 1: 1/21* (4.8%)
Group 2: 3/24* (12.5%)
*3 cases excluded from each
58 mothers refused vaccination
for their babies
CSS 3
EL
EL
type
RCT 1b