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<strong>KCE</strong> reports vol. 6A Prenatale zorg 114 Study Ref Population Intervention Outcomes Results Comments Study type 187 sentinel general practitioners hepatitis B decide collected data each week in 1991 and Presence of Ig against hepatitis B All patients aged what they 1992 virus (HBV) core (anti-HBC/IgM) between 20-49 understoo and HBV surface antigen (HBsAg) years d by clinical were both required to confirm suspicion acute Hepatitis B 55% between 20-29 years Confidence intervals are very large Sensitivity is low Power to detect outbreak is low What is the prevalence of hepatitis B viral infection in pregnant women in the UK? Study Ref Population Intervention Outcomes Results Comments Study Boxall et al., 1994 4 [379] 3522 anonymous serum samples collected from women attending an antenatal clinic in the West Midlands from February 1990 to January 1991 Sera tested for HBsAg using RIA or ELISA and positives confirmed using reverse passive haemagglutination HBsAg prevalence among women of various ethnic origins Overall prevalence 0.56% (20/3522) Breakdown: - 13/20 Asian - 4/20 African- Caribbean - 3/20 SE Asian Prevalence in women EL EL type CSS 3
<strong>KCE</strong> reports vol. 6A Prenatale zorg 115 Study Ref Population Intervention Outcomes Results from immigrant groups 1.04% Comments Study type EL Brook et al., 1989 4 [380] 6226 women attending antenatal clinic at the Royal Free Hospital, London, from 1983/84 to 1988/89 Screening using HBsAg Number of mothers HBsAg positive at first antenatal care visit 33/6226 (0.5%) HBsAg positive at first visit CS 3 Chrystie 4 [381] Stored serum from antenatal clinics Serology Prevalence among In 1988: 38/3760 (1%) CSS 3 et al., 1990 (n = 3760) and 1988 (n = 3975) women screened women HBsAg 1992 Sera of women originally collected for positive rubella in West Lambeth Health In 1990: 35/3975 authority in London (0.9%) women HBsAg positive Derso et 4 [382] Approximately 240,000 pregnant Serum screening using HBsAg Prevalence of HBsAg 297 pregnant women CSS 3 al., 1978 women from antenatal clinics in West carriage in pregnant were HBsAg positive Midlands, England, from May 1974 to mothers May 1977 Overall prevalence of approx 1/850 (0.1%) What is the prevalence of congenital hepatitis B virus in the UK? Study Ref Population Intervention Outcomes Results Comments Study Ramsay et al., 1998 4 [385] England and Wales from 1985 to 1996 Surveillance of laboratory reported cases to PHLS communicable disease surveillance centres Infection in children (under 15 years) Number of cases due to mother-to-child transmission Estimated annual number of perinatal transmissions which lead to chronic carriage Total of 173 cases reported 37/173 (21%) due to mother-to-child transmission 93/116 cases of perinatal transmission leading to carriage per year Assumption that 80% of perinatal infections lead to chronic carriage EL type CSS 3 Derso et 4 Approximately 240,000 Serum screening Infants HBsAg positive beyond Antigen detected in cord The paper states that 297 COM 3
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KCE reports 1. Effectiviteit en kos
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