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KCE reports vol. 6A Prenatale zorg 111
What is the impact of primary prevention on the seroconversion rate during pregnancy?
Study Ref Population Intervention Outcomes Results Comments Study
Adler
et al.,
1996
17 Seronegative women
whose child was less
than 36 months of age,
was shedding
cytomegalovirus and was
enrolled in 1 of 15 daycare
centers in
Richmond during 3
years
Non pregnant women were
randomly (each day-care center
was randomly assigned to 1 of 3
groups) assigned to 3 groups.
1. Mothers in the education
group (E) were given
instructions about protective
behaviours and risky behaviours
to avoid
2. The adherence and education
group (A) received in addition
to the procedures for group E,
social reinforcement for
adherence and problem solving
for any perceived problems
with the behavioural
recommendations
3. The control group (C)
received no intervention
A 4 th group of pregnant women
received an intervention
equivalent to that of the
education group
Seroconversion
Time from enrolment to
infection
Seroconversion:
8 of 17 women in group C
4 of 11 women in group E
2 of 8 women in group A
0 of 14 pregnant women (4 th group)
Time from enrolment to infection:
C and E: average time: 4 months
(range: 2-7)
A: 1 seroconverted at 3 months and
1 at 8 months
Small sample size
Intervention and
control group
were not
randomised
EL
type
CSNR 2a
Does the presence of maternal antibodies to CMV reduce the risk of congenital CMV infection in future pregnancies?
Study Ref Populatio Interventio Outcome Results Comment Study EL
n n s
s type
Fowler et al., 2003 18 3461 Newborns Congenit Prevalence of congenital infection in the group of newborns born to
CH 2b
multiparo were al CMV initially seronegative mothers: