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KCE reports vol. 6A Prenatale zorg 110
Cytomegalovirus
Study Ref Population Intervention Outcomes Results Comments Study
Revello and
Gerna, 2002
Nigro et al.,
2005
16 Sate of the art on diagnosis and management of human
cytomegalovirus infection in the mother, fetus and
157
pregnant
women
with a
primary
CMV
infection
during or
a few
moths
before
pregnancy,
in eight
Italian
cities,
from 1995
to 2003
Therapy group
(n=45)= women
whose amniotic
fluid contained
either CMV or
CMV DNA and
who were offered
intravenous CMV
hyperimmune
globulin at a dose
of 200 U per
kilogram of
maternal weight
Prevention group
(n=84) = women
with a recent
primary infection,
before 21
weeks´gestation or
who declined
amniocentesis and
who were offered
monthly
hyperimmune
globulin (100 U per
kilogram
intravenously)
Rate of congenital CMV
disease
newborn infant
In the therapy group:
31 received hyperimmune globulin:
o 1/31 (3%) of whom gave birth to an infant
with CMV disease
14 women did not receive hyperimmune globulin:
o 7/14 (50%) of whom gave birth to an
infant with CMV disease
Hyperimmune globulin therapy was associated with
a significantly lower risk of congenital CMV disease
(adjusted OR 0.02, 95% CI -¥ to 0.15, p