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KCE reports vol. 6A Prenatale zorg 109
Study Ref Population Intervention Outcomes Results Comments Study type EL
Conclusion:
20% of congenitally infected
infants had severe sequelae.
An additional 17% had
audiological deficits at 1 year
of age. Severe sequelae may
occure after both primary and
recurrent maternal CMV
infection
Does screening pregnant women for cytomegalovirus infection lead to improved maternal and perinatal outcomes?
Study Ref Populatio Interventio Outcome Results Comment
n n s
s
Bolyard et al., 1998 4 [377] Repeated testing is necessary to identify CMV because it can be shed
Stagno and
Whitley, 1985
Seropositivity does not offer complete protection against maternal
reinfection and subsequent fetal infection
4 [378]
No currently available vaccines or prophylactic therapy
Maternal immunity does not prevent virus reactivation nor transmission
to fetus
No effective drug therapy for CMV or its transmission exists
No ways to determine whether intrauterine transmission has occurred
No way to determine whether infected infant will have serious sequelae
Study
type
EL
GL 4
RV 4