Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 108
Study Ref Population Intervention Outcomes Results Comments
pregnancy are not
recognised
Study
type
What is the prevalence of congenital cytomegalovirus (CMV) infection and sequelae of congenital CMV infection?
Study Ref Population Intervention Outcomes Results Comments Study type EL
Casteels 15 3075 unselected pregnant Evaluation of a screening
et al.,
women
program for the
1999
detection of congenital
cytomegalovirus:
- For each liveborn
child:
urine collection for
CMV culture
- For each foetus
expelled after a 2nd Prevalence of 15/3075 = 0.49%
Prospectiv 3
congenital CMV
e OB
infection - 9/15 due to primary
maternal infection
- 5/15 due to recurrent
maternal infection
- 1/15 not possible to
determine
- 3/15 severe sequelae
o 2/3
trimester abortion
termination of
and each stillborn
pregnancy
infant:
o 1/3 neonatal
evaluation for a
death
possible congenital
o 1/3 due to
CMVinfection
recurrent
- For each congenital
maternal
infection stored
infection
maternal sera were
- 12/15 without severe
analysed to
sequelae
determine whether
o 2/12 hearing
maternal infection
disorders (1/2
was primary or
due to primary
recurrent
infection and
½ due to
recurrent
infection)
EL