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KCE reports vol. 6A Prenatale zorg 106
Study Ref Population
February 1988.
Intervention
from June 1988
to June 1996
Intervention Outcomes Results Comments Study
type
What is the effect of intrapartum antimicrobial prophylaxis on the incidence and ecology of the EO neonatal sepsis?
Study Ref Population Intervention Outcomes Results Comments Study
Moore
et al.,
2003
73 23 studies, 14
from single
hospitals, the
rest multi-
centre
Most studies
based in the
USA, 1 in
Canada, 2 in
Australia
2. e. Cytomegalovirus
To identify possible effects of
intrapartum antimicrobial
prophylaxis for prevention of
group-B-streptococcal disease on
the incidence and ecology of earlyonset
neonatal sepsis
Trends in the incidence of
all-cause, GBS, non-GBS or
antibiotic-resistant earlyonset
infections during an
era when IAP use was
increasing
Association between IAP
exposure and risk of
resistant non-GBS
colonisation or infection
Substantial declines in the
incidence of early-onset infections
due to GBS and in some settings,
other bacteria.
Increases in the frequencies of
non-GBS or antimicrobialresistant
early-onset sepsis have
been limited to preterm, lowbirth
weight, very-low-birth
weight neonates
Trend in incidence
could be
multifactorial
Results of analyses
of selected
populations are not
generalisable
What is the immunity-status of Belgian pregnant women against cytomegalovirus (CMV) ?
Study Ref Population Intervention Outcomes Results Comments Study
Donder
s et al.,
1997
65 1340 eligible women presenting for
routine prenatal care at Gasthuisberg
University Hospital in Leuven, Belgium
during 1993
At the beginning of
pregnancy a routine
screening was
offered in one single
bloodtube for the
following:
- Anti-CMV IgG
(1043 women
Prevalence of anti-
CMV IgG: 16% at age
18 and 50% at age 40
(mean 28.3%)
Deficient immunity
against rubella:
15/1268 (1.2%)
Refusal rate for HIVscreening
was 27%
EL
EL
type
SR 3
EL
type
CSS 3