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KCE reports vol. 6A Prenatale zorg 105
Study Ref Population Intervention Outcomes Results Comments Study
type
antepartum prevent early-onset infection and Early-onset GBS
from references of
period monotherapy to prevent
None of the antepartum other recent
transmission in antepartum period
treatment studies reported an reviews
5 trials on or intrapartum period vs. no
effect on neonatal infections
intrapartum treatment
prophylaxis
Reduction of 80% in early-onset
GBS with intrapartum antibiotic
RCTs and
treatment (pooled OR 0.188,
controlled
trials
95%CI 0.07 to 0.53)
Schrag
et al.,
2000
Jeffrey
and
Moses,
1998
4
[447]
4
[448]
7867 cases of
invasive GBS
disease in
counties from
8 states in the
USA from
1993 to 1998
All neonates
admitted to
neonatal unit in
Sydney,
Australia.
Background
incidence
determined
from
November
1986 to
Active surveillance of microbiology
laboratories and analysis with
census data
Screening all women at 28 weeks
(or 24 weeks with known risk
factors for preterm birth) with low
vaginal swab, cultured on a blood
agar. Treatment of all carriers with
intravenous ampicillin in labour
(1g/6 hour until delivery)
Incidence of early-onset
disease from 1993 to 1998
and corresponding dates of
guideline releases
Incidence of early-onset GBS
before and after intervention
Decline from 1.7/1000 live births
in 1993 to 0.6/1000 live births in
1998 (65% decrease, p