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KCE reports vol. 6A Prenatale zorg 103
Study Ref Population Intervention Outcomes Results Comments Study
type
practices in Colonies with
cultures were
Chicago, USA suggestive
575/1272 GBS carriers were restudied at delivery. excluded
from April haemolysis or
1979 to Sept morphology
Of 182 antenatal positive vaginal and rectal cultures,
1981
identified as
GBS with
132/182 (73%) were positive at delivery
CAMP test
Of 67 antenatal positive vaginal cultures, 46/67 (69%)
were positive at delivery
Yancey
et al.,
1996
4
[439]
826 women
attending
antenatal clinics
in the USA
Women with
positive
prenatal
cultures,
cultures
obtained again
intrapartum
and within
three days of
delivery
200 women
with negative
prenatal
cultures
Vaginal and
rectal swabs at
approx 35 to
36 weeks
gestation and
again at
delivery
Overall colonisation rate
Test performance by
culture-delivery interval
Of 144 antenatal positive vaginal cultures, 86/144 (60%)
were positive at delivery
Of 200 antenatal negative vaginal and rectal cultures,
17/200 (9%) were positive at delivery
Estimated sensitivity and specificity of prenatal culture:
70% and 90%, respectively
GBS identified in 219/826 (26.5%) of
women
In cultures obtained 1 to 5 weeks before delivery,
sensitivity 87% (95% CI 83% to 92%), specificity 96% (95%
CI 95% to
98%)
Among patients cultured 6 weeks or more
before delivery, sensitivity 43% and
specificity 85%
EL
CSS 3