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KCE reports vol. 6A Prenatale zorg 101
What are the diagnostic tests available for antenatal detection of GBS carriage and how do they compare in terms of specificity, sensitivity,
and cost-effectiveness?
Study Ref Population Intervention Outcomes Results Comments Study EL
type
Schrag 4 A stratified Universal Prevention of early onset Risk of early-onset disease lower in universally screened Retrospective study CH 2b
et al., [443] random sample culture GBS disease in infants less group: adjusted relative risk 0.46 (95% CI 0.36 to 0.60)
2002
of 5144 live screening vs. than 7 days old
births were screening by
After excluding all women with risk factors and adequate
selected from assessment of
time for prophylaxis, adjusted relative risk was still
629,912 live clinical risk
similar: 0.48 (95% CI 0.37 to 0.63)
births from factors to
1998 and 1999 identify
from 8 candidates for
geographical intrapartum
areas in the antibiotics for
USA. All births
of infants with
early-onset
infection were
included in the
sample (n =
312)
GBS
Spieker 4 240 pregnant Patients Cultures positive for GBS 24% (24/240) cultures positive for GBS
CSS 3
et al., [442] women at 28 received
1999
weeks of written
patient sensitivity 79%, physician sensitivity 83%, p =
gestation in instructions on
0.365
Florida, USA how to obtain
rectovaginal
swab and
obtained own
swab.
Physician also
obtained swab