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<strong>KCE</strong> reports vol. 6A Prenatale zorg 100 2. d. Streptococcus group B What is the prevalence of streptococcus group B in pregnant women in Belgium? Study Ref Population Intervention Outcomes Results Comments Study Donder s et al., 1997 Belgian Health Council , 2003 65 254 unselected women presenting for routine gynaecologic care in an academic hospital in Flanders (Belgium) 13 Belgian pregnant women ICON R Rapid antigen immune assay, aerobic culture and microscopic wet mount evaluation on a vaginal specimen Prevalence 10.6% Women were not necessary pregnant EL type CSS 3 Rectovaginal colonization 13-25% GL 4 What is the prevalence of GBS infection in the neonate and what are the consequences? Study Ref Population Intervention Outcomes Results Comments Study Belgian Health Council , 2003 13 Belgian neonates Early-onset disease Early-onset disease: Attack rate in 1999: 2/1,000 live births Mortality: >14% Meningitis: 10% Late-onset disease: Occurrence: about 1 case for 5 early-onset diseases Trend in incidence could be multifactorial Results of analyses of selected populations are not generalisable EL type GL 4
<strong>KCE</strong> reports vol. 6A Prenatale zorg 101 What are the diagnostic tests available for antenatal detection of GBS carriage and how do they compare in terms of specificity, sensitivity, and cost-effectiveness? Study Ref Population Intervention Outcomes Results Comments Study EL type Schrag 4 A stratified Universal Prevention of early onset Risk of early-onset disease lower in universally screened Retrospective study CH 2b et al., [443] random sample culture GBS disease in infants less group: adjusted relative risk 0.46 (95% CI 0.36 to 0.60) 2002 of 5144 live screening vs. than 7 days old births were screening by After excluding all women with risk factors and adequate selected from assessment of time for prophylaxis, adjusted relative risk was still 629,912 live clinical risk similar: 0.48 (95% CI 0.37 to 0.63) births from factors to 1998 and 1999 identify from 8 candidates for geographical intrapartum areas in the antibiotics for USA. All births of infants with early-onset infection were included in the sample (n = 312) GBS Spieker 4 240 pregnant Patients Cultures positive for GBS 24% (24/240) cultures positive for GBS CSS 3 et al., [442] women at 28 received 1999 weeks of written patient sensitivity 79%, physician sensitivity 83%, p = gestation in instructions on 0.365 Florida, USA how to obtain rectovaginal swab and obtained own swab. Physician also obtained swab
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KCE reports 1. Effectiviteit en kos
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