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KCE reports vol. 6A Prenatale zorg 99
Study Ref Population Intervention Outcomes Results Comments Study
type
Watson et
al., 2002
72 30 comparative studies:
asymptomatic, young,
sexually active
populations with a low
prevalence (< of = 5%)
Nucleic acid
amplification
techniques:
LCR
PCR
Gene probe (GP)
Enzyme immuno
assay (EIA)
Direct
immunofluorescence
(DFA)
Leucocyte esterase
test (LET)
Culture
OR of a false
negative result
by test and
sample
RNA-DNA hybridisation sensitivity range
70% to 85%, rapid and reliable, suitable for
large numbers and requires invasive
samples
Nucleic acid amplification sensitivity range
70% to 95%, also has high specificity (97%
to 99%), suitable for large numbers of
samples, invasive and noninvasive samples
may be used, but expensive and inhibitors
may be a problem in urine samples
LCR, urine: 0.33 (0.13-0.8)
PCR, cervix: 0.26 (0.12-0.54)
PCR, urine: 0.84 (0.37-1.89)
Gene probe, cervix: 0.84 (0.37-1.89)
Gene probe, urine: 0.44 (0.15-1.26)
EIA, cervix: 4.1 (1.15-14.59)
EIA, urine: 1.86 (0.39-8.75)
DFA, cervix: 1.05 (0.09-12.93)
LET, urine: 47.02 (6.21-356.04)
The gold standard, culture,
does not perform as well
as the test against it is
compared
SR of
COM´
s
EL
3