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<strong>KCE</strong> reports vol. 6A Prenatale zorg 96 Study Ref Population Intervention Outcomes Results cultures positive by 9 months of age Comments Study type Does screening women for chlamydial infection in pregnancy lead to improved maternal and perinatal outcomes? Study Ref Population Intervention Outcomes Results Comments Study Brocklehurst and Rooney, 2002 Ryan et al., 1990 4 [369] 11 RCTs included Antibiotic therapy or alternative antibiotic therapy vs. placebo or no treatment for chlamydia in pregnant women 4 [368] 11,544 women cultured at their first prenatal care visit Tennessee, USA, from September 1982 through August 1985 Cervical culture at first antenatal care visit and prospective follow up Women who presented from September 1982 through December 1983 were not treated (n = 1110) Women who presented from Jan 1984 through Aug 1985 were treated with erythromycin (n = Eradication of maternal infection Preterm delivery Side effects, endometritis and neonatal death: no significant difference Prevalence Low birth weight Infant death Number of women with positive cultures reduced by 90% when treated with antibiotics compared with placebo; OR 0.06 (95% CI 0.03 to 0.12) Preterm delivery OR 0.89 (0.51 to 1.56) Side effects, endometritis and neonatal death: no significant difference 21.1% (n = 2433/11544) were positive for chlamydia Increase in low birth weight in untreated group vs. treated group (19.6% vs. 11.0%, p < 0.0001, RR 1.78, 95% CI 1.48 to 2.18) No difference between treated and culture negative group (RR 0.94, 95% CI 0.79 to 1.10) Decrease in survival in untreated EL EL Being updated type SR 1a Historical cohort different calendar periods could explain observed differences Infant death defined as those who did not leave the hospital alive CH 2b
<strong>KCE</strong> reports vol. 6A Prenatale zorg 97 Study Ref Population Intervention Outcomes Results Comments Study type 1323) group vs. treated group (97.6% vs. 99.4%, p < 0.001, RR 0.98, 95% CI 0.97 to 0.99) Treated also more likely to survive than culture-negative group (99.4% vs. 98.5%, p < 0.01, RR 1.01, 95% CI 1.0 to 1.01) EL
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KCE reports 1. Effectiviteit en kos
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