Download het volledig rapport (302 p.) - KCE
Download het volledig rapport (302 p.) - KCE
Download het volledig rapport (302 p.) - KCE
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<strong>KCE</strong> reports vol. 6A Prenatale zorg 95<br />
What are the maternal and perinatal outcomes associated with chlamydial infection in pregnancy?<br />
Study Ref Population Intervention Outcomes Results Comments Study<br />
Preece et<br />
al., 1989<br />
Schachter<br />
et al., 1986<br />
4 [370] 3309 women screened for<br />
chlamydia in a district<br />
hospital in England, from<br />
September 1985 through<br />
August 1986<br />
4 [371] 131 neonates of 262<br />
pregnant women who<br />
tested positive for<br />
chlamydia in obstetric<br />
clinic in San Francisco<br />
hospital, from 1977 to<br />
1983<br />
Screening for chlamydia in pregnant<br />
mothers on presentation in labour<br />
with ELISA<br />
Infants of mothers with chlamydia<br />
seen at 3, 6, 12, and 26 weeks<br />
Screening of all pregnant women who<br />
presented for their first antenatal<br />
care visit and prospective follow-up<br />
of their infants plus 46 control infants<br />
whose mothers had negative<br />
chlamydia cultures before delivery<br />
Neonatal C.<br />
trachomatis<br />
infection<br />
Neonatal<br />
conjunctivitis<br />
Respiratory<br />
infection<br />
Neonatal<br />
deaths<br />
Culture positive<br />
for chlamydia in<br />
newborn<br />
Conjunctivitis in<br />
the newborn<br />
Pneumonia in<br />
the neonate<br />
198 mothers positive for<br />
chlamydial antigen<br />
identified<br />
174 of the 198 infants<br />
followed-up<br />
Culture positive 25% (n =<br />
43/174)<br />
11% (n = 20/174) infants<br />
had neonatal conjunctivitis<br />
3% (n = 6/174) infants<br />
developed lower<br />
respiratory tract infections<br />
Neonatal death 4% (n =<br />
5/131)<br />
36% (n = 47/131) cultured<br />
positive for chlamydia<br />
17.6% (n = 23/131)<br />
neonatal conjunctivitis<br />
16% (n = 21/131) had<br />
pneumonia<br />
None of the controls<br />
developed any clinical<br />
disease due to C.<br />
trachomatis nor were any<br />
Only babies born to<br />
women with<br />
chlamydia followed<br />
up<br />
Only 50% of infants<br />
born to infected<br />
mothers were<br />
followed up<br />
All women who were<br />
delivered by<br />
caesarean section or<br />
who refused or had<br />
moved were<br />
excluded<br />
EL<br />
type<br />
CSS 3<br />
COM 3
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